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Assay Detail

CHEMBL756273

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human ORL1 orphanin receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Nociceptin receptor (CHEMBL2014)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

From hit to lead. Analyzing structure-profile relationships.
Poulain R, Horvath D, Bonnet B, Eckhoff C, Chapelain B, Bodinier MC, Déprez B.
J Med Chem (2001) 44 : 3391 -3401
PubMed 11585444 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 6.55 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL115222 1 7.72
CHEMBL114379 1 7.42
CHEMBL115652 1 7.01
CHEMBL420863 1 6.55
CHEMBL326962 1 6.47
CHEMBL325945 1 6.36
CHEMBL325750 1 6.12
CHEMBL114484 1 5.72
CHEMBL115280 1 5.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL115222 IC50 = 19.0 nM 7.72
CHEMBL114379 IC50 = 38.0 nM 7.42
CHEMBL115652 IC50 = 97.0 nM 7.01
CHEMBL420863 IC50 = 283.0 nM 6.55
CHEMBL326962 IC50 = 340.0 nM 6.47
CHEMBL325945 IC50 = 434.0 nM 6.36
CHEMBL325750 IC50 = 758.0 nM 6.12
CHEMBL114484 IC50 = 1910.0 nM 5.72
CHEMBL115280 IC50 = 2420.0 nM 5.62