Assay Detail
Binding
CHEMBL756428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory effect on binding of [3H]DPDPE to opioid receptor delta in guinea pig cerebellum membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.97 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384584 | — | — | 1 | 8.68 |
| CHEMBL413160 | — | — | 1 | 6.83 |
| CHEMBL407529 | — | — | 1 | 6.75 |
| CHEMBL265387 | — | — | 1 | 6.35 |
| CHEMBL425806 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384584 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL413160 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL407529 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL265387 | — | Ki | = | 449.0 | nM | 6.35 |
| CHEMBL425806 | — | Ki | = | 558.0 | nM | 6.25 |