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Assay Detail

CHEMBL756445

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Functional
In vitro antimalarial activity against human malaria parasite, P falciparum (Vietnam Smith strain)
ChEMBL ↗
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Synthesis and antimalarial activity of 2-aziridinyl- and 2,3-bis(aziridinyl)-1,4-naphthoquinonyl sulfonate and acylate derivatives.
Lin TS, Zhu LY, Xu SP, Divo AA, Sartorelli AC.
J Med Chem (1991) 34 : 1634 -1639
PubMed 2033589 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 65 5.81 7.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL43926 — — 1 7.62
CHEMBL34462 — — 1 7.06
CHEMBL288764 — — 1 7.02
CHEMBL297336 — — 1 6.89
CHEMBL43927 — — 1 6.85
CHEMBL434402 — — 1 6.80
CHEMBL43001 — — 1 6.80
CHEMBL291171 — — 1 6.77
CHEMBL284304 — — 1 6.70
CHEMBL441038 — — 1 6.64
CHEMBL44291 — — 1 6.55
CHEMBL263420 — — 1 6.54
CHEMBL289525 — — 1 6.48
CHEMBL41049 — — 1 6.37
CHEMBL288682 — — 1 6.35
CHEMBL44507 — — 1 6.33
CHEMBL42005 — — 1 6.33
CHEMBL43162 — — 1 6.31
CHEMBL43049 — — 1 6.31
CHEMBL296697 — — 1 6.28
CHEMBL297819 — — 1 6.27
CHEMBL42468 — — 1 6.21
CHEMBL296919 — — 1 5.82
CHEMBL44308 — — 1 5.80
CHEMBL285648 — — 1 5.80
CHEMBL44499 — — 1 5.77
CHEMBL290452 — — 1 5.66
CHEMBL440852 — — 1 5.62
CHEMBL287540 — — 1 5.62
CHEMBL295316 PLUMBAGIN 1.0 1 5.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL43926 — IC50 = 24.0 nM 7.62
CHEMBL34462 — IC50 = 88.0 nM 7.06
CHEMBL288764 — IC50 = 96.0 nM 7.02
CHEMBL297336 — IC50 = 130.0 nM 6.89
CHEMBL43927 — IC50 = 140.0 nM 6.85
CHEMBL434402 — IC50 = 160.0 nM 6.80
CHEMBL43001 — IC50 = 160.0 nM 6.80
CHEMBL291171 — IC50 = 170.0 nM 6.77
CHEMBL284304 — IC50 = 200.0 nM 6.70
CHEMBL441038 — IC50 = 230.0 nM 6.64
CHEMBL44291 — IC50 = 280.0 nM 6.55
CHEMBL263420 — IC50 = 290.0 nM 6.54
CHEMBL289525 — IC50 = 330.0 nM 6.48
CHEMBL41049 — IC50 = 430.0 nM 6.37
CHEMBL288682 — IC50 = 450.0 nM 6.35
CHEMBL44507 — IC50 = 470.0 nM 6.33
CHEMBL42005 — IC50 = 470.0 nM 6.33
CHEMBL43162 — IC50 = 490.0 nM 6.31
CHEMBL43049 — IC50 = 490.0 nM 6.31
CHEMBL296697 — IC50 = 530.0 nM 6.28
CHEMBL297819 — IC50 = 540.0 nM 6.27
CHEMBL42468 — IC50 = 620.0 nM 6.21
CHEMBL296919 — IC50 = 1500.0 nM 5.82
CHEMBL44308 — IC50 = 1600.0 nM 5.80
CHEMBL285648 — IC50 = 1600.0 nM 5.80
CHEMBL44499 — IC50 = 1700.0 nM 5.77
CHEMBL290452 — IC50 = 2200.0 nM 5.66
CHEMBL440852 — IC50 = 2400.0 nM 5.62
CHEMBL287540 — IC50 = 2400.0 nM 5.62
CHEMBL295316 PLUMBAGIN IC50 = 2400.0 nM 5.62
CHEMBL295754 — IC50 = 2600.0 nM 5.58
CHEMBL42238 — IC50 = 2600.0 nM 5.58
CHEMBL43539 — IC50 = 2900.0 nM 5.54
CHEMBL287272 — IC50 = 3000.0 nM 5.52
CHEMBL36304 — IC50 = 3000.0 nM 5.52
CHEMBL34251 — IC50 = 3000.0 nM 5.52
CHEMBL284093 — IC50 = 3200.0 nM 5.50
CHEMBL35618 — IC50 = 3200.0 nM 5.50
CHEMBL45038 — IC50 = 3400.0 nM 5.47
CHEMBL590 MENADIONE IC50 = 3400.0 nM 5.47
CHEMBL35665 — IC50 = 3400.0 nM 5.47
CHEMBL288630 — IC50 = 3600.0 nM 5.44
CHEMBL289457 — IC50 = 3700.0 nM 5.43
CHEMBL43612 JUGLONE IC50 = 3700.0 nM 5.43
CHEMBL42106 — IC50 = 3700.0 nM 5.43
CHEMBL42151 — IC50 = 3700.0 nM 5.43
CHEMBL43907 — IC50 = 3900.0 nM 5.41
CHEMBL287601 — IC50 = 3900.0 nM 5.41
CHEMBL35363 — IC50 = 4000.0 nM 5.40
CHEMBL34027 — IC50 = 4000.0 nM 5.40