Assay Detail
Binding
CHEMBL756487
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Tested in vitro for inhibiting the 50% binding of Peroxisome proliferator activated receptor alpha
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.53 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147095 | — | — | 1 | 7.34 |
| CHEMBL147384 | — | — | 1 | 7.25 |
| CHEMBL356382 | — | — | 1 | 6.97 |
| CHEMBL358379 | — | — | 1 | 6.90 |
| CHEMBL446629 | — | — | 1 | 6.86 |
| CHEMBL148797 | — | — | 1 | 6.76 |
| CHEMBL343210 | — | — | 1 | 6.75 |
| CHEMBL147935 | — | — | 1 | 6.39 |
| CHEMBL148459 | — | — | 1 | 6.33 |
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 6.31 |
| CHEMBL359285 | — | — | 1 | 5.73 |
| CHEMBL149876 | — | — | 1 | 5.72 |
| CHEMBL146650 | — | — | 1 | 5.60 |
| CHEMBL149835 | — | — | 1 | - |
| CHEMBL342292 | — | — | 1 | - |
| CHEMBL356707 | — | — | 1 | - |
| CHEMBL149647 | — | — | 1 | - |
| CHEMBL146231 | — | — | 1 | - |
| CHEMBL147090 | — | — | 1 | - |
| CHEMBL148950 | — | — | 1 | - |
| CHEMBL146301 | — | — | 1 | - |
| CHEMBL358325 | — | — | 1 | - |
| CHEMBL146806 | — | — | 1 | - |
| CHEMBL149715 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147095 | — | Ki | = | 45.71 | nM | 7.34 |
| CHEMBL147384 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL356382 | — | Ki | = | 107.15 | nM | 6.97 |
| CHEMBL358379 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL446629 | — | Ki | = | 138.04 | nM | 6.86 |
| CHEMBL148797 | — | Ki | = | 173.78 | nM | 6.76 |
| CHEMBL343210 | — | Ki | = | 177.83 | nM | 6.75 |
| CHEMBL147935 | — | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL148459 | — | Ki | = | 467.74 | nM | 6.33 |
| CHEMBL107367 | FARGLITAZAR | Ki | = | 489.78 | nM | 6.31 |
| CHEMBL359285 | — | Ki | = | 1862.09 | nM | 5.73 |
| CHEMBL149876 | — | Ki | = | 1905.46 | nM | 5.72 |
| CHEMBL146650 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL149835 | — | Ki | < | 3019.95 | nM | - |
| CHEMBL342292 | — | Ki | < | 3019.95 | nM | - |
| CHEMBL356707 | — | Ki | < | 3019.95 | nM | - |
| CHEMBL149647 | — | Ki | < | 3019.95 | nM | - |
| CHEMBL146231 | — | Ki | < | 3019.95 | nM | - |
| CHEMBL147090 | — | Ki | < | 3019.95 | nM | - |
| CHEMBL148950 | — | Ki | < | 3019.95 | nM | - |
| CHEMBL146301 | — | Ki | < | 3019.95 | nM | - |
| CHEMBL358325 | — | Ki | < | 3019.95 | nM | - |
| CHEMBL146806 | — | Ki | < | 3019.95 | nM | - |
| CHEMBL149715 | — | Ki | < | 3019.95 | nM | - |