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Assay Detail

CHEMBL756488

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested in vitro for inhibiting the 50% binding of Peroxisome proliferator activated receptor alpha
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Peroxisome proliferator-activated receptor alpha (CHEMBL239)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.
Collins JL, Blanchard SG, Boswell GE, Charifson PS, Cobb JE, Henke BR, Hull-Ryde EA, Kazmierski WM, Lake DH, Leesnitzer LM, Lehmann J, Lenhard JM, Orband-Miller LA, Gray-Nunez Y, Parks DJ, Plunkett KD, Tong WQ.
J Med Chem (1998) 41 : 5037 -5054
PubMed 9836621 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.85 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145941 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145941 Ki = 1412.54 nM 5.85