Assay Detail
Functional
CHEMBL756829
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Inhibition of LPS-stimulated TNF-alpha release from human peripheral blood mononuclear cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.06 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304523 | — | — | 1 | 7.75 |
| CHEMBL66600 | — | — | 1 | 7.57 |
| CHEMBL65541 | — | — | 1 | 7.51 |
| CHEMBL63983 | — | — | 1 | 7.36 |
| CHEMBL306667 | — | — | 1 | 7.36 |
| CHEMBL304416 | — | — | 1 | 7.27 |
| CHEMBL63442 | — | — | 1 | 7.13 |
| CHEMBL66601 | — | — | 1 | 6.53 |
| CHEMBL307336 | — | — | 1 | 6.43 |
| CHEMBL291834 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304523 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL66600 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL65541 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL63983 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL306667 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL304416 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL63442 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL66601 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL307336 | — | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL291834 | — | IC50 | = | 1930.0 | nM | 5.71 |