Assay Detail
Functional
CHEMBL756831
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Inhibition of TNF-alpha release from human peripheral blood mononuclear cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: a potent and selective phosphodiesterase type 4D inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.52 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77826 | — | — | 1 | 7.17 |
| CHEMBL74078 | — | — | 1 | 6.94 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77826 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL74078 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 3467.0 | nM | 5.46 |