Assay Detail
Binding
CHEMBL756856
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hydrolysis of nitrocefin after 5 min pre-incubation with P99 beta-lactamases (class C)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of bridged gamma-lactams as analogues of beta-lactam antibiotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.30 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606647 | — | — | 1 | 4.60 |
| CHEMBL84953 | — | — | 1 | 4.00 |
| CHEMBL82450 | — | — | 1 | - |
| CHEMBL85008 | — | — | 1 | - |
| CHEMBL83309 | — | — | 1 | - |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606647 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL84953 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL82450 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL85008 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL83309 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL777 | CLAVULANIC ACID | IC50 | > | 1000000.0 | nM | - |