Assay Detail
Binding
CHEMBL756940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Canine Tracheal Smooth Muscle PDE 4
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.83 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330646 | — | — | 1 | 6.82 |
| CHEMBL95669 | — | — | 1 | 6.28 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.80 |
| CHEMBL321948 | — | — | 1 | 5.70 |
| CHEMBL329961 | — | — | 1 | 5.60 |
| CHEMBL143079 | — | — | 1 | 5.44 |
| CHEMBL323555 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330646 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL95669 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL321948 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL329961 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL143079 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL323555 | — | IC50 | = | 6600.0 | nM | 5.18 |