Assay Detail
Binding
CHEMBL757146
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Inhibition of protein kinase A.
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent and selective PKC inhibitory 5-membered ring analogs of balanol with replacement of the carboxamide moiety
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.50 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48636 | — | — | 1 | 7.52 |
| CHEMBL49354 | — | — | 2 | 7.40 |
| CHEMBL265559 | — | — | 1 | 7.16 |
| CHEMBL300422 | — | — | 1 | 6.50 |
| CHEMBL48546 | — | — | 1 | 5.39 |
| CHEMBL48988 | — | — | 1 | 4.30 |
| CHEMBL295806 | — | — | 2 | - |
| CHEMBL48665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48636 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL49354 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL49354 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL265559 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL300422 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL48546 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL48988 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL295806 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL295806 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL48665 | — | IC50 | > | 50000.0 | nM | - |