Assay Detail
Binding
CHEMBL757153
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of Penicillin-binding protein 3 from Staphylococcus aureus (Schoch).
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Penicillin-binding protein 2b (CHEMBL2565) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.54 | 4.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333330 | — | — | 1 | 4.55 |
| CHEMBL123481 | — | — | 1 | 4.52 |
| CHEMBL332565 | — | — | 1 | - |
| CHEMBL121924 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333330 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL123481 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL332565 | — | IC50 | = | 286000.0 | nM | - |
| CHEMBL121924 | — | IC50 | = | 145000.0 | nM | - |