Assay Detail
Binding
CHEMBL757332
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Binding affinity against opioid receptor delta from guinea pig brain membranes using [3H]DADLE as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective reversible and irreversible ligands for the kappa opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.10 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73226 | — | — | 1 | 5.79 |
| CHEMBL118865 | SPIRADOLINE | 2.0 | 1 | 5.03 |
| CHEMBL307235 | — | — | 1 | 5.02 |
| CHEMBL70311 | — | — | 1 | 4.91 |
| CHEMBL73131 | — | — | 1 | 4.76 |
| CHEMBL74010 | — | — | 1 | - |
| CHEMBL290543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73226 | — | Ki | = | 1640.0 | nM | 5.79 |
| CHEMBL118865 | SPIRADOLINE | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL307235 | — | Ki | = | 9510.0 | nM | 5.02 |
| CHEMBL70311 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL73131 | — | Ki | = | 17500.0 | nM | 4.76 |
| CHEMBL74010 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL290543 | — | Ki | > | 10000.0 | nM | - |