Assay Detail
Binding
CHEMBL757333
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Affinity for opioid receptor delta sites
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.51 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2114223 | — | — | 1 | 6.95 |
| CHEMBL89307 | — | — | 1 | 6.82 |
| CHEMBL88168 | — | — | 1 | 6.44 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.34 |
| CHEMBL71294 | — | — | 1 | 6.00 |
| CHEMBL87010 | — | — | 1 | - |
| CHEMBL330449 | — | — | 1 | - |
| CHEMBL290543 | — | — | 1 | - |
| CHEMBL329114 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2114223 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL89307 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL88168 | — | Ki | = | 362.0 | nM | 6.44 |
| CHEMBL70 | MORPHINE | Ki | = | 456.0 | nM | 6.34 |
| CHEMBL71294 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL87010 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL330449 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL290543 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL329114 | — | Ki | > | 1000.0 | nM | - |