Assay Detail
Binding
CHEMBL757334
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Binding affinity was measured on opioid receptor delta sites.
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.32 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2114225 | — | — | 2 | 6.83 |
| CHEMBL2114226 | — | — | 1 | 6.13 |
| CHEMBL433508 | — | — | 1 | 6.00 |
| CHEMBL329343 | — | — | 1 | - |
| CHEMBL88393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2114225 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL2114226 | — | Ki | = | 746.0 | nM | 6.13 |
| CHEMBL433508 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL329343 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2114225 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL88393 | — | Ki | > | 1000.0 | nM | - |