Assay Detail
Functional
CHEMBL757445
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Antiproliferative activity measured against P388CPT5 cells resistant to Topoisomerase I inhibitor Camptothecin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388CPT5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.66 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350558 | — | — | 1 | 6.22 |
| CHEMBL3350560 | — | — | 1 | 6.16 |
| CHEMBL3350555 | — | — | 1 | 5.52 |
| CHEMBL3350556 | — | — | 1 | 5.52 |
| CHEMBL3350563 | — | — | 1 | 5.39 |
| CHEMBL3350564 | — | — | 1 | 5.12 |
| CHEMBL3350557 | — | — | 1 | - |
| CHEMBL3350565 | — | — | 1 | - |
| CHEMBL3350561 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350558 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3350560 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3350555 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3350556 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3350563 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL3350564 | — | IC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL3350557 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3350565 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3350561 | — | IC50 | > | 19900.0 | nM | - |