Assay Detail
Functional
CHEMBL757693
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In vitro inhibition of bone resorption by isolated Human osteoclastoma cells by the number of excavations (pits/bone slice)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.24 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288419 | — | — | 1 | 7.52 |
| CHEMBL41588 | — | — | 1 | 7.52 |
| CHEMBL449696 | — | — | 1 | 7.40 |
| CHEMBL291117 | — | — | 1 | 7.00 |
| CHEMBL39485 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288419 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL41588 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL449696 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL291117 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL39485 | — | IC50 | = | 180.0 | nM | 6.75 |