Assay Detail
Functional
CHEMBL757882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro agonist activity tested for transactivation in human PPAR gamma-Gal4 chimeric COS-1 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | COS-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.95 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430970 | — | — | 1 | 7.70 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 7.70 |
| CHEMBL50885 | — | — | 1 | 7.52 |
| CHEMBL53746 | — | — | 1 | 7.52 |
| CHEMBL300026 | — | — | 1 | 7.22 |
| CHEMBL52426 | — | — | 1 | 7.10 |
| CHEMBL54097 | — | — | 1 | 7.00 |
| CHEMBL52633 | — | — | 1 | 6.92 |
| CHEMBL50143 | — | — | 1 | 6.70 |
| CHEMBL299958 | — | — | 1 | 6.52 |
| CHEMBL301156 | — | — | 1 | 6.52 |
| CHEMBL50755 | — | — | 1 | 6.40 |
| CHEMBL50984 | — | — | 1 | 6.30 |
| CHEMBL298187 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430970 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL50885 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL53746 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL300026 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL52426 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL54097 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL52633 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL50143 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL299958 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL301156 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL50755 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL50984 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL298187 | — | EC50 | = | 700.0 | nM | 6.16 |