Assay Detail
Binding
CHEMBL757883
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In vitro binding affinity against human PPAR gamma (peroxisome proliferator-activated gamma receptor)
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.14 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50143 | — | — | 1 | 6.92 |
| CHEMBL430970 | — | — | 1 | 6.89 |
| CHEMBL53746 | — | — | 1 | 6.89 |
| CHEMBL50680 | — | — | 1 | 6.75 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.60 |
| CHEMBL52633 | — | — | 1 | 6.60 |
| CHEMBL298187 | — | — | 1 | 6.37 |
| CHEMBL50885 | — | — | 1 | 6.34 |
| CHEMBL50572 | — | — | 1 | 6.32 |
| CHEMBL300026 | — | — | 1 | 6.09 |
| CHEMBL50755 | — | — | 1 | 6.00 |
| CHEMBL51603 | — | — | 1 | 5.75 |
| CHEMBL53688 | — | — | 1 | 5.70 |
| CHEMBL52426 | — | — | 1 | 5.70 |
| CHEMBL54197 | — | — | 1 | 5.58 |
| CHEMBL301156 | — | — | 1 | 5.52 |
| CHEMBL50984 | — | — | 1 | 5.24 |
| CHEMBL54097 | — | — | 1 | 5.17 |
| CHEMBL50259 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50143 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL430970 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL53746 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL50680 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL52633 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL298187 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL50885 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL50572 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL300026 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL50755 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL51603 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL53688 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL52426 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL54197 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL301156 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL50984 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL54097 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL50259 | — | IC50 | > | 15000.0 | nM | - |