Assay Detail
Binding
CHEMBL757885
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Inhibition of PDE3 in homogenates of human blood platelets
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel selective PDE4 inhibitors. 1. Synthesis, structure-activity relationships, and molecular modeling of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.82 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85617 | — | — | 1 | 6.60 |
| CHEMBL313842 | ZARDAVERINE | 2.0 | 1 | 6.20 |
| CHEMBL84874 | — | — | 1 | 5.60 |
| CHEMBL316413 | — | — | 2 | 5.40 |
| CHEMBL313111 | — | — | 1 | 5.30 |
| CHEMBL85556 | — | — | 1 | - |
| CHEMBL315981 | — | — | 1 | - |
| CHEMBL83484 | — | — | 1 | - |
| CHEMBL84702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85617 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL313842 | ZARDAVERINE | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL84874 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL316413 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL313111 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL85556 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL315981 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL83484 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL84702 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL316413 | — | IC50 | < | 10000.0 | nM | - |