Assay Detail
Binding
CHEMBL757887
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Inhibition of canine lung Phosphodiesterase 4 (PDE4)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.44 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538498 | — | — | 1 | 6.12 |
| CHEMBL541818 | — | — | 1 | 5.77 |
| CHEMBL544289 | — | — | 1 | 5.44 |
| CHEMBL553371 | — | — | 1 | 5.33 |
| CHEMBL540539 | — | — | 1 | 5.21 |
| CHEMBL553786 | — | — | 1 | 5.16 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538498 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL541818 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL544289 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL553371 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL540539 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL553786 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 8300.0 | nM | 5.08 |