Assay Detail
Binding
CHEMBL757893
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Inhibition of rolipram binding to PDE4 from human neutrophils
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.37 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 8.82 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 8.80 |
| CHEMBL74631 | — | — | 1 | 7.89 |
| CHEMBL308407 | — | — | 1 | 7.80 |
| CHEMBL308158 | — | — | 1 | 7.34 |
| CHEMBL74404 | — | — | 1 | 7.15 |
| CHEMBL70903 | — | — | 1 | 7.02 |
| CHEMBL72362 | — | — | 1 | 6.92 |
| CHEMBL70391 | — | — | 1 | 6.83 |
| CHEMBL309341 | — | — | 1 | 6.79 |
| CHEMBL73640 | — | — | 1 | 6.54 |
| CHEMBL419814 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL63 | ROLIPRAM | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL74631 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL308407 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL308158 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL74404 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL70903 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL72362 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL70391 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL309341 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL73640 | — | Ki | = | 286.0 | nM | 6.54 |
| CHEMBL419814 | — | Ki | = | 320.0 | nM | 6.50 |