Assay Detail
Binding
CHEMBL758014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of PDE-V isolated from porcine pulmonary artery.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.01 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32183 | — | — | 1 | 6.00 |
| CHEMBL28871 | — | — | 1 | 6.00 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 6.00 |
| CHEMBL542813 | — | — | 1 | 6.00 |
| CHEMBL280830 | — | — | 1 | 5.70 |
| CHEMBL286021 | — | — | 1 | 5.52 |
| CHEMBL27627 | — | — | 1 | 5.40 |
| CHEMBL28566 | — | — | 1 | 5.40 |
| CHEMBL417477 | — | — | 1 | 5.22 |
| CHEMBL28835 | — | — | 1 | 5.22 |
| CHEMBL286042 | — | — | 1 | 4.82 |
| CHEMBL31359 | — | — | 1 | 4.75 |
| CHEMBL286020 | SULMAZOLE | 2.0 | 1 | 4.68 |
| CHEMBL281663 | — | — | 1 | 4.62 |
| CHEMBL31954 | — | — | 1 | 4.62 |
| CHEMBL32093 | — | — | 1 | 4.58 |
| CHEMBL432659 | — | — | 1 | 4.48 |
| CHEMBL543042 | — | — | 1 | 4.47 |
| CHEMBL28597 | — | — | 1 | 4.43 |
| CHEMBL28240 | — | — | 1 | 4.40 |
| CHEMBL553515 | — | — | 1 | 4.38 |
| CHEMBL2110680 | ISOMAZOLE | 2.0 | 1 | 4.24 |
| CHEMBL31964 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32183 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL28871 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL542813 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL280830 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL286021 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL27627 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL28566 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL417477 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL28835 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL286042 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL31359 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL286020 | SULMAZOLE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL281663 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL31954 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL32093 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL432659 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL543042 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL28597 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL28240 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL553515 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2110680 | ISOMAZOLE | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL31964 | — | IC50 | = | 64000.0 | nM | 4.19 |