Assay Detail
Binding
CHEMBL758018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1)
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.79 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 6.52 |
| CHEMBL538498 | — | — | 1 | 6.34 |
| CHEMBL542394 | — | — | 1 | 6.26 |
| CHEMBL543818 | — | — | 1 | 6.00 |
| CHEMBL541818 | — | — | 1 | 5.96 |
| CHEMBL553371 | — | — | 1 | 5.89 |
| CHEMBL70432 | — | — | 1 | 5.68 |
| CHEMBL540539 | — | — | 1 | 5.68 |
| CHEMBL423125 | — | — | 1 | 5.58 |
| CHEMBL305028 | — | — | 1 | 5.51 |
| CHEMBL544289 | — | — | 1 | 5.41 |
| CHEMBL538505 | — | — | 1 | 5.41 |
| CHEMBL553786 | — | — | 1 | 5.02 |
| CHEMBL539779 | — | — | 1 | - |
| CHEMBL70382 | — | — | 1 | - |
| CHEMBL545221 | — | — | 1 | - |
| CHEMBL68106 | — | — | 1 | - |
| CHEMBL305014 | — | — | 1 | - |
| CHEMBL71949 | — | — | 1 | - |
| CHEMBL305206 | — | — | 1 | - |
| CHEMBL72423 | — | — | 1 | - |
| CHEMBL544057 | — | — | 1 | - |
| CHEMBL539010 | — | — | 1 | - |
| CHEMBL543351 | — | — | 1 | - |
| CHEMBL542878 | — | — | 1 | - |
| CHEMBL430421 | — | — | 1 | - |
| CHEMBL72875 | — | — | 1 | - |
| CHEMBL305427 | — | — | 1 | - |
| CHEMBL69502 | — | — | 1 | - |
| CHEMBL544995 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL538498 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL542394 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL543818 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL541818 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL553371 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL70432 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL540539 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL423125 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL305028 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL538505 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL544289 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL553786 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL539519 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL553083 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL71478 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL68388 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL539779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL70382 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL545221 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL68106 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL305014 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL71949 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL305206 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL72423 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL544057 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL539010 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL543351 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL542878 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL430421 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL72875 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL305427 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL69502 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL544995 | — | IC50 | > | 10000.0 | nM | - |