Assay Detail
Binding
CHEMBL758019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine adrenal gland Phosphodiesterase 2 (PDE2)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Adrenal gland |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL3477) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.51 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538498 | — | — | 1 | 5.55 |
| CHEMBL541818 | — | — | 1 | 5.46 |
| CHEMBL540539 | — | — | 1 | - |
| CHEMBL553371 | — | — | 1 | - |
| CHEMBL544289 | — | — | 1 | - |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | - |
| CHEMBL553786 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538498 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL541818 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL540539 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL553371 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL544289 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL192 | SILDENAFIL | IC50 | > | 10000.0 | nM | - |
| CHEMBL553786 | — | IC50 | > | 10000.0 | nM | - |