Assay Detail
Binding
CHEMBL758020
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Inhibitory activity against canine heart Phosphodiesterase 3 (PDE3)
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.17 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544995 | — | — | 1 | 5.36 |
| CHEMBL538498 | — | — | 1 | 5.08 |
| CHEMBL70432 | — | — | 1 | 5.07 |
| CHEMBL541818 | — | — | 1 | - |
| CHEMBL69502 | — | — | 1 | - |
| CHEMBL540539 | — | — | 1 | - |
| CHEMBL553083 | — | — | 1 | - |
| CHEMBL71478 | — | — | 1 | - |
| CHEMBL68388 | — | — | 1 | - |
| CHEMBL539779 | — | — | 1 | - |
| CHEMBL553371 | — | — | 1 | - |
| CHEMBL545221 | — | — | 1 | - |
| CHEMBL72875 | — | — | 1 | - |
| CHEMBL542394 | — | — | 1 | - |
| CHEMBL71949 | — | — | 1 | - |
| CHEMBL305206 | — | — | 1 | - |
| CHEMBL544289 | — | — | 1 | - |
| CHEMBL538505 | — | — | 1 | - |
| CHEMBL305028 | — | — | 1 | - |
| CHEMBL72423 | — | — | 1 | - |
| CHEMBL544057 | — | — | 1 | - |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | - |
| CHEMBL543351 | — | — | 1 | - |
| CHEMBL542878 | — | — | 1 | - |
| CHEMBL543818 | — | — | 1 | - |
| CHEMBL430421 | — | — | 1 | - |
| CHEMBL305427 | — | — | 1 | - |
| CHEMBL553786 | — | — | 1 | - |
| CHEMBL423125 | — | — | 1 | - |
| CHEMBL305014 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544995 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL538498 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL70432 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL542394 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL539010 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL72875 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL545221 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL553371 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL539779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL68388 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL71478 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL553083 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL540539 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL69502 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL541818 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL539519 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL70382 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL68106 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL71949 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL305206 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL544289 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL538505 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL305028 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL72423 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL544057 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL192 | SILDENAFIL | IC50 | > | 10000.0 | nM | - |
| CHEMBL543351 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL542878 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL543818 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL430421 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL305427 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL553786 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL423125 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL305014 | — | IC50 | > | 10000.0 | nM | - |