Assay Detail
Binding
CHEMBL758175
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Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligand
52
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 52 | 7.13 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | 2.0 | 2 | 9.24 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | — | 3 | 8.96 |
| CHEMBL2367604 | — | — | 1 | 8.60 |
| CHEMBL2367916 | — | — | 3 | 8.28 |
| CHEMBL355403 | — | — | 1 | 8.21 |
| CHEMBL169346 | — | — | 3 | 8.12 |
| CHEMBL169536 | — | — | 1 | 8.08 |
| CHEMBL422567 | — | — | 1 | 7.96 |
| CHEMBL2367918 | — | — | 1 | 7.92 |
| CHEMBL169345 | — | — | 1 | 7.89 |
| CHEMBL55851 | — | — | 1 | 7.72 |
| CHEMBL354172 | — | — | 1 | 7.70 |
| CHEMBL422563 | — | — | 1 | 7.68 |
| CHEMBL169030 | — | — | 1 | 7.58 |
| CHEMBL168392 | — | — | 1 | 7.54 |
| CHEMBL422560 | — | — | 1 | 7.54 |
| CHEMBL2368318 | — | — | 1 | 7.46 |
| CHEMBL352965 | — | — | 1 | 7.43 |
| CHEMBL301835 | — | — | 2 | 7.27 |
| CHEMBL352827 | — | — | 1 | 7.21 |
| CHEMBL440196 | — | — | 1 | 7.12 |
| CHEMBL168913 | — | — | 1 | 7.10 |
| CHEMBL353303 | — | — | 1 | 7.01 |
| CHEMBL353938 | — | — | 1 | 7.00 |
| CHEMBL52399 | — | — | 1 | 6.96 |
| CHEMBL56165 | — | — | 1 | 6.80 |
| CHEMBL352365 | — | — | 1 | 6.77 |
| CHEMBL169670 | — | — | 1 | 6.75 |
| CHEMBL354322 | — | — | 1 | 6.66 |
| CHEMBL168409 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL56585 | CYCLAZOCINE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL2367604 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL2367916 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL355403 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL169346 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL169536 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL2367916 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL422567 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2367918 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL169345 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL55851 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL354172 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL422563 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL169030 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL422560 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL168392 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL2368318 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL352965 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL169346 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL301835 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL301835 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL352827 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL440196 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL168913 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL169346 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL353303 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL353938 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL52399 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL56165 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL352365 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL169670 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL354322 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL168409 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL55392 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL170384 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL2367916 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL2368317 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL55434 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL291751 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL293951 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL299114 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL2368320 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL2021605 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL299114 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL55948 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL55248 | — | Ki | = | 2800.0 | nM | 5.55 |