Assay Detail
Binding
CHEMBL758176
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Opioid receptor delta 1 in guinea pig brain membranes using [3H]naltrindole as radioligand
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.95 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | — | 1 | 9.66 |
| CHEMBL90667 | — | — | 1 | 9.27 |
| CHEMBL1790045 | — | — | 1 | 9.21 |
| CHEMBL419511 | — | — | 1 | 9.07 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 8.89 |
| CHEMBL93731 | — | — | 1 | 8.59 |
| CHEMBL327935 | — | — | 1 | 8.51 |
| CHEMBL327576 | — | — | 1 | 8.51 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | — | 1 | 8.47 |
| CHEMBL328269 | — | — | 1 | 8.39 |
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 8.38 |
| CHEMBL420995 | — | — | 1 | 8.25 |
| CHEMBL90463 | — | — | 1 | 8.25 |
| CHEMBL327309 | — | — | 1 | 8.16 |
| CHEMBL328236 | — | — | 1 | 8.07 |
| CHEMBL327885 | — | — | 1 | 8.00 |
| CHEMBL430833 | — | — | 1 | 7.64 |
| CHEMBL2115245 | — | — | 1 | 7.57 |
| CHEMBL314294 | — | — | 1 | 7.57 |
| CHEMBL327490 | — | — | 1 | 7.54 |
| CHEMBL2114257 | — | — | 1 | 7.48 |
| CHEMBL92774 | — | — | 1 | 7.48 |
| CHEMBL91231 | — | — | 1 | 7.38 |
| CHEMBL329020 | — | — | 1 | 7.29 |
| CHEMBL329453 | — | — | 1 | 7.16 |
| CHEMBL90305 | — | — | 1 | 6.96 |
| CHEMBL92349 | — | — | 1 | 6.89 |
| CHEMBL96785 | — | — | 1 | 6.38 |
| CHEMBL290543 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL90667 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL1790045 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL419511 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL93731 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL327935 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL327576 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL328269 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL592 | LEVORPHANOL | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL420995 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL90463 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL327309 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL328236 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL327885 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL430833 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2115245 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL314294 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL327490 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL2114257 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL92774 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL91231 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL329020 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL329453 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL90305 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL92349 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL96785 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL290543 | — | Ki | = | 2500.0 | nM | 5.60 |