Assay Detail
Binding
CHEMBL758181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for binding affinity against [3H]- Cl-DPDPE labeled Opioid receptor delta 1 in guinea-pig brain homogenate.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
6N-Cinnamoyl--naltrexamine and its p-nitro derivative. High efficacy -opioid agonists with weak antagonist actions
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.15 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473362 | — | — | 1 | 8.51 |
| CHEMBL296693 | — | — | 1 | 8.30 |
| CHEMBL417535 | — | — | 1 | 8.29 |
| CHEMBL297756 | — | — | 1 | 8.02 |
| CHEMBL473136 | — | — | 1 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473362 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL296693 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL417535 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL297756 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL473136 | — | Ki | = | 22.4 | nM | 7.65 |