Assay Detail
Functional
CHEMBL758309
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In vitro antimalarial activity against Plasmodium falciparum FCR3
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.01 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136613 | — | — | 1 | 9.57 |
| CHEMBL479432 | FEBRIFUGINE | — | 1 | 9.15 |
| CHEMBL110619 | — | — | 1 | 8.80 |
| CHEMBL137542 | — | — | 1 | 8.66 |
| CHEMBL105789 | ISOFEBRIFUGINE | — | 1 | 8.47 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.00 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.75 |
| CHEMBL423905 | — | — | 1 | 7.66 |
| CHEMBL341165 | — | — | 1 | 6.82 |
| CHEMBL136204 | — | — | 1 | 5.18 |
| CHEMBL136423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136613 | — | EC50 | = | 0.27 | nM | 9.57 |
| CHEMBL479432 | FEBRIFUGINE | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL110619 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL137542 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL105789 | ISOFEBRIFUGINE | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL423905 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL341165 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL136204 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL136423 | — | EC50 | > | 52000.0 | nM | - |