Assay Detail
Functional
CHEMBL758314
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against chloroquine-resistant Plasmodium falciparum K1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.54 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447526 | — | — | 1 | 8.09 |
| CHEMBL94521 | — | — | 1 | 7.91 |
| CHEMBL1630 | — | — | 1 | 7.84 |
| CHEMBL30020 | — | — | 1 | 7.72 |
| CHEMBL97395 | — | — | 1 | 7.65 |
| CHEMBL98566 | — | — | 1 | 6.82 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447526 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL94521 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL1630 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL30020 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL97395 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL98566 | — | IC50 | = | 151.6 | nM | 6.82 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 183.0 | nM | 6.74 |