Assay Detail
Functional
CHEMBL758315
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.51 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148195 | — | — | 1 | 8.01 |
| CHEMBL146616 | — | — | 1 | 7.89 |
| CHEMBL344105 | — | — | 1 | 7.88 |
| CHEMBL146617 | — | — | 1 | 7.82 |
| CHEMBL146945 | — | — | 1 | 7.65 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.72 |
| CHEMBL148139 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148195 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL146616 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL344105 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL146617 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL146945 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL148139 | — | IC50 | = | 240.0 | nM | 6.62 |