Assay Detail
Functional
CHEMBL758316
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In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.54 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147860 | — | — | 1 | 8.22 |
| CHEMBL1630 | — | — | 1 | 7.82 |
| CHEMBL147587 | ISOQUINE | — | 1 | 7.75 |
| CHEMBL147876 | — | — | 1 | 7.73 |
| CHEMBL147616 | — | — | 1 | 7.69 |
| CHEMBL342575 | — | — | 1 | 7.66 |
| CHEMBL147541 | — | — | 1 | 7.58 |
| CHEMBL433926 | — | — | 1 | 7.51 |
| CHEMBL147806 | GSK-369796 | 1.0 | 1 | 7.49 |
| CHEMBL146826 | DESETHYL ISOQUINE | — | 1 | 7.49 |
| CHEMBL148326 | — | — | 1 | 7.43 |
| CHEMBL148170 | — | — | 1 | 6.95 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147860 | — | IC50 | = | 6.01 | nM | 8.22 |
| CHEMBL1630 | — | IC50 | = | 15.08 | nM | 7.82 |
| CHEMBL147587 | ISOQUINE | IC50 | = | 17.63 | nM | 7.75 |
| CHEMBL147876 | — | IC50 | = | 18.65 | nM | 7.73 |
| CHEMBL147616 | — | IC50 | = | 20.28 | nM | 7.69 |
| CHEMBL342575 | — | IC50 | = | 21.75 | nM | 7.66 |
| CHEMBL147541 | — | IC50 | = | 26.22 | nM | 7.58 |
| CHEMBL433926 | — | IC50 | = | 30.63 | nM | 7.51 |
| CHEMBL147806 | GSK-369796 | IC50 | = | 32.75 | nM | 7.49 |
| CHEMBL146826 | DESETHYL ISOQUINE | IC50 | = | 32.42 | nM | 7.49 |
| CHEMBL148326 | — | IC50 | = | 37.21 | nM | 7.43 |
| CHEMBL148170 | — | IC50 | = | 112.37 | nM | 6.95 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 183.82 | nM | 6.74 |