Assay Detail
Functional
CHEMBL758317
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Inhibitory activity against chloroquine-resistant Plasmodium falciparum THAI
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.81 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447526 | — | — | 1 | 8.17 |
| CHEMBL1630 | — | — | 1 | 8.14 |
| CHEMBL94521 | — | — | 1 | 7.89 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.84 |
| CHEMBL97395 | — | — | 1 | 7.81 |
| CHEMBL30020 | — | — | 1 | 7.76 |
| CHEMBL98566 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447526 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1630 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL94521 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL97395 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL30020 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL98566 | — | IC50 | = | 89.6 | nM | 7.05 |