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Assay Detail

CHEMBL758318

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Functional
Inhibitory activity against Plasmodium falciparum W2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases.
Woodard CL, Li Z, Kathcart AK, Terrell J, Gerena L, Lopez-Sanchez M, Kyle DE, Bhattacharjee AK, Nichols DA, Ellis W, Prigge ST, Geyer JA, Waters NC.
J Med Chem (2003) 46 : 3877 -3882
PubMed 12930149 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.40 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL388978 STAUROSPORINE 1 6.82
CHEMBL126077 INDIRUBIN-3-MONOXIME 1 5.96
CHEMBL296586 KENPAULLONE 1 5.42
CHEMBL50894 ALSTERPAULLONE 1 5.37
CHEMBL280074 OLOMOUCINE 1 5.10
CHEMBL23327 PURVALANOLA 1 5.04
CHEMBL1242973 BUTYROLACTONE I 1 4.93
CHEMBL14762 SELICICLIB 2.0 1 4.55
CHEMBL1213804 1 -
CHEMBL127798 1 -
CHEMBL126602 1 -
CHEMBL126408 1 -
CHEMBL363491 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL388978 STAUROSPORINE IC50 = 150.0 nM 6.82
CHEMBL126077 INDIRUBIN-3-MONOXIME IC50 = 1100.0 nM 5.96
CHEMBL296586 KENPAULLONE IC50 = 3800.0 nM 5.42
CHEMBL50894 ALSTERPAULLONE IC50 = 4300.0 nM 5.37
CHEMBL280074 OLOMOUCINE IC50 = 8000.0 nM 5.10
CHEMBL23327 PURVALANOLA IC50 = 9200.0 nM 5.04
CHEMBL1242973 BUTYROLACTONE I IC50 = 11700.0 nM 4.93
CHEMBL14762 SELICICLIB IC50 = 28000.0 nM 4.55
CHEMBL1213804 IC50 > 15200.0 nM -
CHEMBL127798 IC50 > 14400.0 nM -
CHEMBL126602 IC50 > 20000.0 nM -
CHEMBL126408 IC50 > 14600.0 nM -
CHEMBL363491 IC50 > 15200.0 nM -