Assay Detail
Functional
CHEMBL758322
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Inhibition of Plasmodium falciparum T9/94 mutant
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.98 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329687 | — | — | 1 | 7.62 |
| CHEMBL93974 | — | — | 1 | 7.54 |
| CHEMBL91345 | — | — | 1 | 7.41 |
| CHEMBL93889 | — | — | 1 | 7.36 |
| CHEMBL93893 | — | — | 1 | 6.75 |
| CHEMBL90292 | — | — | 1 | 6.60 |
| CHEMBL93888 | — | — | 1 | 6.60 |
| CHEMBL90018 | — | — | 1 | 6.50 |
| CHEMBL90703 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329687 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL93974 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL91345 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL93889 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL93893 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL90292 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL93888 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL90018 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL90703 | — | IC50 | = | 365.0 | nM | 6.44 |