Assay Detail
Functional
CHEMBL758323
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Inhibition of Plasmodium falciparum T9/94 mutant
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.30 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93153 | — | — | 1 | 7.72 |
| CHEMBL13636 | — | — | 1 | 7.55 |
| CHEMBL443013 | — | — | 1 | 6.82 |
| CHEMBL93748 | — | — | 1 | 6.56 |
| CHEMBL90461 | — | — | 1 | 6.56 |
| CHEMBL7130 | — | — | 1 | 6.53 |
| CHEMBL93001 | — | — | 1 | 6.51 |
| CHEMBL92846 | — | — | 1 | 6.45 |
| CHEMBL6742 | — | — | 1 | 6.35 |
| CHEMBL92182 | — | — | 1 | 6.33 |
| CHEMBL92047 | — | — | 1 | 6.31 |
| CHEMBL89959 | — | — | 1 | 6.29 |
| CHEMBL94281 | — | — | 1 | 6.14 |
| CHEMBL7005 | — | — | 1 | 6.00 |
| CHEMBL6741 | — | — | 1 | 5.56 |
| CHEMBL264392 | — | — | 1 | 5.55 |
| CHEMBL433204 | — | — | 1 | 5.55 |
| CHEMBL90358 | — | — | 1 | 5.46 |
| CHEMBL7004 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93153 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL13636 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL443013 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL93748 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL90461 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL7130 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL93001 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL92846 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL6742 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL92182 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL92047 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL89959 | — | IC50 | = | 517.0 | nM | 6.29 |
| CHEMBL94281 | — | IC50 | = | 725.0 | nM | 6.14 |
| CHEMBL7005 | — | IC50 | = | 1001.0 | nM | 6.00 |
| CHEMBL6741 | — | IC50 | = | 2759.0 | nM | 5.56 |
| CHEMBL264392 | — | IC50 | = | 2818.0 | nM | 5.55 |
| CHEMBL433204 | — | IC50 | = | 2818.0 | nM | 5.55 |
| CHEMBL90358 | — | IC50 | = | 3446.0 | nM | 5.46 |
| CHEMBL7004 | — | IC50 | = | 3617.0 | nM | 5.44 |