Assay Detail
Binding
CHEMBL758902
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Inhibitory concentration against human orexin-1 receptor (hOX1R)
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.42 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344622 | — | — | 1 | 5.95 |
| CHEMBL140700 | — | — | 1 | 5.64 |
| CHEMBL140547 | — | — | 1 | 5.44 |
| CHEMBL343786 | — | — | 1 | 5.43 |
| CHEMBL140348 | — | — | 1 | 5.42 |
| CHEMBL343551 | — | — | 1 | 5.28 |
| CHEMBL139083 | — | — | 1 | 5.26 |
| CHEMBL138091 | — | — | 1 | 5.23 |
| CHEMBL138101 | — | — | 1 | 5.16 |
| CHEMBL342583 | — | — | 1 | - |
| CHEMBL337367 | — | — | 1 | - |
| CHEMBL140559 | — | — | 1 | - |
| CHEMBL139158 | — | — | 1 | - |
| CHEMBL141368 | — | — | 1 | - |
| CHEMBL140260 | — | — | 1 | - |
| CHEMBL342039 | — | — | 1 | - |
| CHEMBL139634 | — | — | 1 | - |
| CHEMBL142009 | — | — | 1 | - |
| CHEMBL140504 | — | — | 1 | - |
| CHEMBL337159 | — | — | 1 | - |
| CHEMBL435826 | — | — | 1 | - |
| CHEMBL343141 | — | — | 1 | - |
| CHEMBL139915 | — | — | 1 | - |
| CHEMBL444602 | — | — | 1 | - |
| CHEMBL139117 | — | — | 1 | - |
| CHEMBL139157 | — | — | 1 | - |
| CHEMBL342363 | — | — | 1 | - |
| CHEMBL138717 | — | — | 1 | - |
| CHEMBL139223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344622 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL140700 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL140547 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL343786 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL140348 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL343551 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL139083 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL138091 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL138101 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL342583 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL337367 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL140559 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL139158 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL141368 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL140260 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL342039 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL139634 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL142009 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL140504 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL337159 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL435826 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL343141 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL139915 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL444602 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL139117 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL139157 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL342363 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL138717 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL139223 | — | IC50 | > | 10000.0 | nM | - |