Assay Detail
Functional
CHEMBL758982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
-log concentration required to induce 50% maximum lipogenic activity against Peroxisome proliferator activated receptor gamma
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 46 | 7.33 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148300 | — | — | 1 | 9.37 |
| CHEMBL106666 | GW7845 | — | 1 | 9.21 |
| CHEMBL149780 | — | — | 1 | 8.84 |
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 8.83 |
| CHEMBL145958 | — | — | 1 | 8.57 |
| CHEMBL2112870 | — | — | 1 | 8.51 |
| CHEMBL148668 | — | — | 1 | 8.49 |
| CHEMBL345541 | — | — | 1 | 8.46 |
| CHEMBL148596 | — | — | 1 | 8.36 |
| CHEMBL146355 | — | — | 1 | 8.16 |
| CHEMBL2112871 | — | — | 1 | 8.07 |
| CHEMBL150232 | — | — | 1 | 7.91 |
| CHEMBL147770 | — | — | 1 | 7.89 |
| CHEMBL150215 | — | — | 1 | 7.84 |
| CHEMBL148384 | — | — | 1 | 7.77 |
| CHEMBL149714 | — | — | 1 | 7.62 |
| CHEMBL146637 | — | — | 1 | 7.57 |
| CHEMBL359333 | — | — | 1 | 7.20 |
| CHEMBL146821 | — | — | 1 | 7.18 |
| CHEMBL146217 | — | — | 1 | 7.16 |
| CHEMBL146579 | — | — | 1 | 7.15 |
| CHEMBL146562 | — | — | 1 | 7.14 |
| CHEMBL146584 | — | — | 1 | 7.11 |
| CHEMBL421781 | — | — | 1 | 7.02 |
| CHEMBL149381 | — | — | 1 | 7.02 |
| CHEMBL414442 | — | — | 1 | 6.97 |
| CHEMBL347788 | — | — | 1 | 6.88 |
| CHEMBL145886 | — | — | 1 | 6.81 |
| CHEMBL145824 | — | — | 1 | 6.76 |
| CHEMBL146258 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148300 | — | EC50 | = | 0.4266 | nM | 9.37 |
| CHEMBL106666 | GW7845 | EC50 | = | 0.6166 | nM | 9.21 |
| CHEMBL149780 | — | EC50 | = | 1.445 | nM | 8.84 |
| CHEMBL107367 | FARGLITAZAR | EC50 | = | 1.479 | nM | 8.83 |
| CHEMBL145958 | — | EC50 | = | 2.692 | nM | 8.57 |
| CHEMBL2112870 | — | EC50 | = | 3.09 | nM | 8.51 |
| CHEMBL148668 | — | EC50 | = | 3.236 | nM | 8.49 |
| CHEMBL345541 | — | EC50 | = | 3.467 | nM | 8.46 |
| CHEMBL148596 | — | EC50 | = | 4.365 | nM | 8.36 |
| CHEMBL146355 | — | EC50 | = | 6.918 | nM | 8.16 |
| CHEMBL2112871 | — | EC50 | = | 8.511 | nM | 8.07 |
| CHEMBL150232 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL147770 | — | EC50 | = | 12.88 | nM | 7.89 |
| CHEMBL150215 | — | EC50 | = | 14.45 | nM | 7.84 |
| CHEMBL148384 | — | EC50 | = | 16.98 | nM | 7.77 |
| CHEMBL149714 | — | EC50 | = | 23.99 | nM | 7.62 |
| CHEMBL146637 | — | EC50 | = | 26.92 | nM | 7.57 |
| CHEMBL359333 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL146821 | — | EC50 | = | 66.07 | nM | 7.18 |
| CHEMBL146217 | — | EC50 | = | 69.18 | nM | 7.16 |
| CHEMBL146579 | — | EC50 | = | 70.79 | nM | 7.15 |
| CHEMBL146562 | — | EC50 | = | 72.44 | nM | 7.14 |
| CHEMBL146584 | — | EC50 | = | 77.62 | nM | 7.11 |
| CHEMBL421781 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL149381 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL414442 | — | EC50 | = | 107.15 | nM | 6.97 |
| CHEMBL347788 | — | EC50 | = | 131.83 | nM | 6.88 |
| CHEMBL145886 | — | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL145824 | — | EC50 | = | 173.78 | nM | 6.76 |
| CHEMBL146258 | — | EC50 | = | 177.83 | nM | 6.75 |
| CHEMBL347076 | — | EC50 | = | 338.84 | nM | 6.47 |
| CHEMBL147419 | — | EC50 | = | 363.08 | nM | 6.44 |
| CHEMBL2112020 | — | EC50 | = | 371.54 | nM | 6.43 |
| CHEMBL147021 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL147282 | — | EC50 | = | 676.08 | nM | 6.17 |
| CHEMBL149309 | — | EC50 | = | 724.44 | nM | 6.14 |
| CHEMBL146530 | — | EC50 | = | 758.58 | nM | 6.12 |
| CHEMBL147912 | — | EC50 | = | 891.25 | nM | 6.05 |
| CHEMBL359150 | — | EC50 | = | 977.24 | nM | 6.01 |
| CHEMBL344776 | — | EC50 | = | 1174.9 | nM | 5.93 |
| CHEMBL145938 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL146687 | — | EC50 | < | 1000.0 | nM | - |
| CHEMBL342990 | — | EC50 | < | 2511.89 | nM | - |
| CHEMBL2112021 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL356353 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL149147 | — | EC50 | < | 5011.87 | nM | - |