Assay Detail
Functional
CHEMBL758983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to promote differentiation of C3H10T1/2 stem cells to adipocytes using lipogenesis assay mediated through activation of Peroxisome proliferator activated receptor gamma
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.54 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 8.83 |
| CHEMBL423026 | — | — | 1 | 8.36 |
| CHEMBL434063 | — | — | 2 | 7.74 |
| CHEMBL146822 | — | — | 1 | 7.33 |
| CHEMBL148301 | — | — | 1 | 6.44 |
| CHEMBL147826 | — | — | 1 | 6.33 |
| CHEMBL346219 | — | — | 1 | 6.30 |
| CHEMBL148060 | — | — | 1 | 6.24 |
| CHEMBL146614 | — | — | 1 | 6.02 |
| CHEMBL147694 | — | — | 1 | 5.94 |
| CHEMBL357479 | — | — | 1 | 5.94 |
| CHEMBL145829 | — | — | 1 | 5.91 |
| CHEMBL343469 | — | — | 1 | 5.88 |
| CHEMBL146322 | — | — | 1 | 5.87 |
| CHEMBL359377 | — | — | 1 | 5.82 |
| CHEMBL146123 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | EC50 | = | 1.479 | nM | 8.83 |
| CHEMBL423026 | — | EC50 | = | 4.365 | nM | 8.36 |
| CHEMBL434063 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL146822 | — | EC50 | = | 46.77 | nM | 7.33 |
| CHEMBL148301 | — | EC50 | = | 363.08 | nM | 6.44 |
| CHEMBL147826 | — | EC50 | = | 467.74 | nM | 6.33 |
| CHEMBL346219 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL148060 | — | EC50 | = | 575.44 | nM | 6.24 |
| CHEMBL146614 | — | EC50 | = | 954.99 | nM | 6.02 |
| CHEMBL147694 | — | EC50 | = | 1148.15 | nM | 5.94 |
| CHEMBL357479 | — | EC50 | = | 1148.15 | nM | 5.94 |
| CHEMBL145829 | — | EC50 | = | 1230.27 | nM | 5.91 |
| CHEMBL343469 | — | EC50 | = | 1318.26 | nM | 5.88 |
| CHEMBL146322 | — | EC50 | = | 1348.96 | nM | 5.87 |
| CHEMBL359377 | — | EC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL146123 | — | EC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL434063 | — | EC50 | < | 1000.0 | nM | - |