Assay Detail
Functional
CHEMBL758984
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to promote differentiation of C3H10T1/2 stem cells to adipocytes using lipogenesis assay mediated through activation of Peroxisome proliferator activated receptor gamma
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 7.34 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 8.83 |
| CHEMBL147384 | — | — | 1 | 8.83 |
| CHEMBL147095 | — | — | 1 | 8.75 |
| CHEMBL356382 | — | — | 1 | 8.75 |
| CHEMBL358379 | — | — | 1 | 8.67 |
| CHEMBL148797 | — | — | 1 | 8.56 |
| CHEMBL358325 | — | — | 1 | 8.44 |
| CHEMBL148459 | — | — | 1 | 8.30 |
| CHEMBL446629 | — | — | 1 | 8.19 |
| CHEMBL147090 | — | — | 1 | 8.13 |
| CHEMBL148950 | — | — | 1 | 8.04 |
| CHEMBL343210 | — | — | 1 | 7.83 |
| CHEMBL149876 | — | — | 1 | 7.81 |
| CHEMBL147935 | — | — | 1 | 7.74 |
| CHEMBL342292 | — | — | 1 | 7.49 |
| CHEMBL146301 | — | — | 1 | 7.40 |
| CHEMBL149647 | — | — | 1 | 6.92 |
| CHEMBL359285 | — | — | 1 | 6.75 |
| CHEMBL146231 | — | — | 1 | 6.47 |
| CHEMBL146806 | — | — | 1 | 6.41 |
| CHEMBL149605 | — | — | 1 | 6.35 |
| CHEMBL149677 | — | — | 1 | 6.34 |
| CHEMBL146650 | — | — | 1 | 6.29 |
| CHEMBL149715 | — | — | 1 | 6.26 |
| CHEMBL149835 | — | — | 1 | 6.16 |
| CHEMBL356707 | — | — | 1 | 6.14 |
| CHEMBL343459 | — | — | 1 | 6.12 |
| CHEMBL145941 | — | — | 1 | 6.12 |
| CHEMBL147599 | — | — | 1 | 6.07 |
| CHEMBL147492 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | EC50 | = | 1.479 | nM | 8.83 |
| CHEMBL147384 | — | EC50 | = | 1.479 | nM | 8.83 |
| CHEMBL147095 | — | EC50 | = | 1.778 | nM | 8.75 |
| CHEMBL356382 | — | EC50 | = | 1.778 | nM | 8.75 |
| CHEMBL358379 | — | EC50 | = | 2.138 | nM | 8.67 |
| CHEMBL148797 | — | EC50 | = | 2.754 | nM | 8.56 |
| CHEMBL358325 | — | EC50 | = | 3.631 | nM | 8.44 |
| CHEMBL148459 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL446629 | — | EC50 | = | 6.457 | nM | 8.19 |
| CHEMBL147090 | — | EC50 | = | 7.413 | nM | 8.13 |
| CHEMBL148950 | — | EC50 | = | 9.12 | nM | 8.04 |
| CHEMBL343210 | — | EC50 | = | 14.79 | nM | 7.83 |
| CHEMBL149876 | — | EC50 | = | 15.49 | nM | 7.81 |
| CHEMBL147935 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL342292 | — | EC50 | = | 32.36 | nM | 7.49 |
| CHEMBL146301 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL149647 | — | EC50 | = | 120.23 | nM | 6.92 |
| CHEMBL359285 | — | EC50 | = | 177.83 | nM | 6.75 |
| CHEMBL146231 | — | EC50 | = | 338.84 | nM | 6.47 |
| CHEMBL146806 | — | EC50 | = | 389.05 | nM | 6.41 |
| CHEMBL149605 | — | EC50 | = | 446.68 | nM | 6.35 |
| CHEMBL149677 | — | EC50 | = | 457.09 | nM | 6.34 |
| CHEMBL146650 | — | EC50 | = | 512.86 | nM | 6.29 |
| CHEMBL149715 | — | EC50 | = | 549.54 | nM | 6.26 |
| CHEMBL149835 | — | EC50 | = | 691.83 | nM | 6.16 |
| CHEMBL356707 | — | EC50 | = | 724.44 | nM | 6.14 |
| CHEMBL343459 | — | EC50 | = | 758.58 | nM | 6.12 |
| CHEMBL145941 | — | EC50 | = | 758.58 | nM | 6.12 |
| CHEMBL147599 | — | EC50 | = | 851.14 | nM | 6.07 |
| CHEMBL147492 | — | EC50 | = | 933.25 | nM | 6.03 |