Assay Detail
Functional
CHEMBL758987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of peroxisome proliferator activated receptor gamma measured by induction of 50% of maximum alkaline phosphatase activity, transfection assay in CV-1 cells
32
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 6.76 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 9.47 |
| CHEMBL423026 | — | — | 2 | 8.58 |
| CHEMBL59132 | — | — | 1 | 8.50 |
| CHEMBL358137 | — | — | 1 | 8.30 |
| CHEMBL148301 | — | — | 1 | 8.04 |
| CHEMBL434063 | — | — | 3 | 8.04 |
| CHEMBL17805 | BRL-48482 | — | 1 | 7.95 |
| CHEMBL146822 | — | — | 1 | 7.54 |
| CHEMBL346219 | — | — | 1 | 7.30 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 7.05 |
| CHEMBL147826 | — | — | 1 | 6.97 |
| CHEMBL146614 | — | — | 1 | 6.78 |
| CHEMBL356350 | — | — | 2 | 6.64 |
| CHEMBL343469 | — | — | 1 | 6.35 |
| CHEMBL148060 | — | — | 1 | 6.31 |
| CHEMBL146201 | — | — | 1 | 6.31 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 6.27 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.23 |
| CHEMBL357479 | — | — | 1 | 6.21 |
| CHEMBL144877 | — | — | 1 | 6.16 |
| CHEMBL145829 | — | — | 1 | 6.07 |
| CHEMBL147694 | — | — | 1 | 6.03 |
| CHEMBL146322 | — | — | 1 | 5.86 |
| CHEMBL146123 | — | — | 1 | 5.74 |
| CHEMBL147608 | — | — | 1 | 5.60 |
| CHEMBL346415 | — | — | 1 | 4.99 |
| CHEMBL359377 | — | — | 1 | 4.78 |
| CHEMBL7002 | CIGLITAZONE | 2.0 | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | EC50 | = | 0.3388 | nM | 9.47 |
| CHEMBL423026 | — | EC50 | = | 2.63 | nM | 8.58 |
| CHEMBL423026 | — | EC50 | = | 2.63 | nM | 8.58 |
| CHEMBL59132 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL358137 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL434063 | — | EC50 | = | 9.12 | nM | 8.04 |
| CHEMBL434063 | — | EC50 | = | 9.12 | nM | 8.04 |
| CHEMBL148301 | — | EC50 | = | 9.12 | nM | 8.04 |
| CHEMBL17805 | BRL-48482 | EC50 | = | 11.22 | nM | 7.95 |
| CHEMBL146822 | — | EC50 | = | 28.84 | nM | 7.54 |
| CHEMBL346219 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 89.13 | nM | 7.05 |
| CHEMBL147826 | — | EC50 | = | 107.15 | nM | 6.97 |
| CHEMBL146614 | — | EC50 | = | 165.96 | nM | 6.78 |
| CHEMBL356350 | — | EC50 | = | 229.09 | nM | 6.64 |
| CHEMBL434063 | — | EC50 | = | 389.05 | nM | 6.41 |
| CHEMBL343469 | — | EC50 | = | 446.68 | nM | 6.35 |
| CHEMBL148060 | — | EC50 | = | 489.78 | nM | 6.31 |
| CHEMBL146201 | — | EC50 | = | 489.78 | nM | 6.31 |
| CHEMBL408 | TROGLITAZONE | EC50 | = | 537.03 | nM | 6.27 |
| CHEMBL595 | PIOGLITAZONE | EC50 | = | 588.84 | nM | 6.23 |
| CHEMBL357479 | — | EC50 | = | 616.6 | nM | 6.21 |
| CHEMBL144877 | — | EC50 | = | 691.83 | nM | 6.16 |
| CHEMBL145829 | — | EC50 | = | 851.14 | nM | 6.07 |
| CHEMBL147694 | — | EC50 | = | 933.25 | nM | 6.03 |
| CHEMBL146322 | — | EC50 | = | 1380.38 | nM | 5.86 |
| CHEMBL146123 | — | EC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL147608 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL346415 | — | EC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL359377 | — | EC50 | = | 16595.87 | nM | 4.78 |
| CHEMBL356350 | — | EC50 | = | 21877.62 | nM | 4.66 |
| CHEMBL7002 | CIGLITAZONE | EC50 | = | 22908.68 | nM | 4.64 |