Assay Detail
Binding
CHEMBL759115
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Binding affinity to human Peroxisome proliferator activated receptor gamma using scintillation proximity assay
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.81 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 8.96 |
| CHEMBL106666 | GW7845 | — | 1 | 8.43 |
| CHEMBL104850 | — | — | 2 | 8.16 |
| CHEMBL321634 | — | — | 1 | 7.28 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.92 |
| CHEMBL104246 | — | — | 1 | 6.80 |
| CHEMBL104494 | — | — | 1 | 6.55 |
| CHEMBL326668 | — | — | 1 | 6.44 |
| CHEMBL431448 | — | — | 1 | 6.32 |
| CHEMBL105088 | — | — | 1 | 6.21 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.20 |
| CHEMBL318104 | — | — | 1 | 6.07 |
| CHEMBL107794 | — | — | 1 | 6.01 |
| CHEMBL104458 | — | — | 1 | 5.68 |
| CHEMBL107741 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL106666 | GW7845 | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL104850 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL104850 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL321634 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL121 | ROSIGLITAZONE | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL104246 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL104494 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL326668 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL431448 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL105088 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL595 | PIOGLITAZONE | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL318104 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL107794 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL104458 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL107741 | — | Ki | = | 2600.0 | nM | 5.58 |