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Assay Detail

CHEMBL759117

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Binding
Binding affinity towards peroxisome proliferator activated receptor gamma (PPAR gamma)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Peroxisome proliferator-activated receptor gamma (CHEMBL235)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.
Adams AD, Hu Z, von Langen D, Dadiz A, Elbrecht A, MacNaul KL, Berger JP, Zhou G, Doebber TW, Meurer R, Forrest MJ, Moller DE, Jones AB.
Bioorg Med Chem Lett (2003) 13 : 3185 -3190
PubMed 12951090 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.23 7.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL324856 1 7.06
CHEMBL110295 1 6.98
CHEMBL843 ROSIGLITAZONE MALEATE 4.0 1 6.87
CHEMBL430894 1 6.76
CHEMBL110408 1 6.71
CHEMBL421602 1 6.57
CHEMBL108905 1 6.21
CHEMBL323773 1 6.02
CHEMBL106256 1 6.01
CHEMBL110725 1 5.96
CHEMBL326015 1 5.57
CHEMBL430505 1 5.23
CHEMBL320925 1 5.07
CHEMBL108974 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL324856 Ki = 87.0 nM 7.06
CHEMBL110295 Ki = 104.0 nM 6.98
CHEMBL843 ROSIGLITAZONE MALEATE Ki = 136.0 nM 6.87
CHEMBL430894 Ki = 175.0 nM 6.76
CHEMBL110408 Ki = 197.0 nM 6.71
CHEMBL421602 Ki = 268.0 nM 6.57
CHEMBL108905 Ki = 618.0 nM 6.21
CHEMBL323773 Ki = 956.0 nM 6.02
CHEMBL106256 Ki = 985.0 nM 6.01
CHEMBL110725 Ki = 1100.0 nM 5.96
CHEMBL326015 Ki = 2680.0 nM 5.57
CHEMBL430505 Ki = 5940.0 nM 5.23
CHEMBL320925 Ki = 8530.0 nM 5.07
CHEMBL108974 Ki > 10000.0 nM -