Assay Detail
Functional
CHEMBL759143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested functionally in vitro for inducing 50% of the maximum alkaline phosphate activity (Transactivation) against Peroxisome proliferator activated receptor gamma
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 7.93 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358379 | — | — | 1 | 10.00 |
| CHEMBL147384 | — | — | 1 | 9.90 |
| CHEMBL147095 | — | — | 1 | 9.61 |
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 9.47 |
| CHEMBL356382 | — | — | 1 | 9.22 |
| CHEMBL148459 | — | — | 1 | 8.98 |
| CHEMBL148797 | — | — | 1 | 8.97 |
| CHEMBL358325 | — | — | 1 | 8.89 |
| CHEMBL343210 | — | — | 1 | 8.82 |
| CHEMBL149876 | — | — | 1 | 8.74 |
| CHEMBL148950 | — | — | 1 | 8.74 |
| CHEMBL147090 | — | — | 1 | 8.68 |
| CHEMBL146301 | — | — | 1 | 8.62 |
| CHEMBL147935 | — | — | 1 | 8.43 |
| CHEMBL446629 | — | — | 1 | 8.03 |
| CHEMBL342292 | — | — | 1 | 7.91 |
| CHEMBL146650 | — | — | 1 | 7.63 |
| CHEMBL359285 | — | — | 1 | 7.51 |
| CHEMBL149715 | — | — | 1 | 7.29 |
| CHEMBL149647 | — | — | 1 | 7.09 |
| CHEMBL149605 | — | — | 1 | 6.98 |
| CHEMBL146231 | — | — | 1 | 6.93 |
| CHEMBL147492 | — | — | 1 | 6.62 |
| CHEMBL149677 | — | — | 1 | 6.57 |
| CHEMBL343459 | — | — | 1 | 6.49 |
| CHEMBL149835 | — | — | 1 | 6.42 |
| CHEMBL147599 | — | — | 1 | 5.96 |
| CHEMBL146806 | — | — | 1 | 5.91 |
| CHEMBL356707 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358379 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL147384 | — | EC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL147095 | — | EC50 | = | 0.2455 | nM | 9.61 |
| CHEMBL107367 | FARGLITAZAR | EC50 | = | 0.3388 | nM | 9.47 |
| CHEMBL356382 | — | EC50 | = | 0.6026 | nM | 9.22 |
| CHEMBL148459 | — | EC50 | = | 1.047 | nM | 8.98 |
| CHEMBL148797 | — | EC50 | = | 1.072 | nM | 8.97 |
| CHEMBL358325 | — | EC50 | = | 1.288 | nM | 8.89 |
| CHEMBL343210 | — | EC50 | = | 1.514 | nM | 8.82 |
| CHEMBL149876 | — | EC50 | = | 1.82 | nM | 8.74 |
| CHEMBL148950 | — | EC50 | = | 1.82 | nM | 8.74 |
| CHEMBL147090 | — | EC50 | = | 2.089 | nM | 8.68 |
| CHEMBL146301 | — | EC50 | = | 2.399 | nM | 8.62 |
| CHEMBL147935 | — | EC50 | = | 3.715 | nM | 8.43 |
| CHEMBL446629 | — | EC50 | = | 9.333 | nM | 8.03 |
| CHEMBL342292 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL146650 | — | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL359285 | — | EC50 | = | 30.9 | nM | 7.51 |
| CHEMBL149715 | — | EC50 | = | 51.29 | nM | 7.29 |
| CHEMBL149647 | — | EC50 | = | 81.28 | nM | 7.09 |
| CHEMBL149605 | — | EC50 | = | 104.71 | nM | 6.98 |
| CHEMBL146231 | — | EC50 | = | 117.49 | nM | 6.93 |
| CHEMBL147492 | — | EC50 | = | 239.88 | nM | 6.62 |
| CHEMBL149677 | — | EC50 | = | 269.15 | nM | 6.57 |
| CHEMBL343459 | — | EC50 | = | 323.59 | nM | 6.49 |
| CHEMBL149835 | — | EC50 | = | 380.19 | nM | 6.42 |
| CHEMBL147599 | — | EC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL146806 | — | EC50 | = | 1230.27 | nM | 5.91 |
| CHEMBL356707 | — | EC50 | = | 3019.95 | nM | 5.52 |