Assay Detail
Binding
CHEMBL759158
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Inhibition of canine cardiac fraction III cAMP phosphodiesterase (PDE 3) at 1.875 mg/kg intravenous dose
4
Total Activities
4
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.62 | 4.89 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| DOSE | DOSE | 1.875 | mg.kg-1 | — |
| ROUTE | ROUTE | - | — | Intravenous |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30001 | — | — | 1 | 4.89 |
| CHEMBL30387 | — | — | 1 | 4.75 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | 4.22 |
| CHEMBL435758 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30001 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL30387 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL12856 | INAMRINONE | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL435758 | — | IC50 | = | 300000.0 | nM | - |