Assay Detail
Binding
CHEMBL759166
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Inhibitory concentration against cAMP PDE III enzyme in guinea pig
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.24 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282765 | TETRAHYDROBENXIMIDAZOLE | — | 1 | 6.82 |
| CHEMBL30623 | — | — | 1 | 5.96 |
| CHEMBL30402 | — | — | 1 | 5.92 |
| CHEMBL30368 | — | — | 1 | 5.64 |
| CHEMBL30908 | — | — | 1 | 5.46 |
| CHEMBL286502 | — | — | 1 | 5.39 |
| CHEMBL58728 | — | — | 1 | 4.92 |
| CHEMBL448467 | — | — | 1 | 4.66 |
| CHEMBL30367 | — | — | 1 | 4.40 |
| CHEMBL31105 | — | — | 1 | 4.30 |
| CHEMBL30362 | — | — | 1 | 4.13 |
| CHEMBL31112 | — | — | 1 | - |
| CHEMBL30358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282765 | TETRAHYDROBENXIMIDAZOLE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL30623 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL30402 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL30368 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL30908 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL286502 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL58728 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL448467 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL30367 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL31105 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL30362 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL31112 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL30358 | — | IC50 | = | 220000.0 | nM | - |