Assay Detail

CHEMBL759174

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Functional

Ability to block depolarization induced 45Ca uptake into pheochromocytoma PC12 cells

ChEMBL ↗

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Target

PC-12 (CHEMBL612556) ↗

Open DB target context

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Primary target PC-12

CHEMBL612556

Anchored from Assay target.

Protein identity PC-12

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Cell Type	PC-12
Confidence	1 — Organism
Curated By	Intermediate

Target

PC-12 (CHEMBL612556) ↗

Type	CELL-LINE
Organism	Rattus norvegicus

Publication

New developments in Ca2+ channel antagonists.

Janis RA, Triggle DJ.
J Med Chem (1983) 26 : 775 -785
PubMed 6304312 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.00	8.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL475534	NITRENDIPINE	3.0	1	8.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL475534	NITRENDIPINE	IC50	=	10.0	nM	8.00