Assay Detail
Functional
CHEMBL759185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration at which 50% of the maximal effect (stimulation of PLC at P2Y1 receptor in the turkey erythrocyte membranes) is reached
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Meleagris gallopavo |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.62 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3144305 | — | — | 1 | 7.70 |
| CHEMBL3144171 | — | — | 1 | 6.26 |
| CHEMBL1199057 | — | — | 1 | 6.19 |
| CHEMBL3144153 | — | — | 1 | 5.77 |
| CHEMBL3144310 | — | — | 1 | 5.70 |
| CHEMBL574817 | — | — | 1 | 5.63 |
| CHEMBL607338 | — | — | 1 | 5.52 |
| CHEMBL3144180 | — | — | 1 | 5.35 |
| CHEMBL1230817 | — | — | 1 | 5.20 |
| CHEMBL3706406 | — | — | 1 | 5.19 |
| CHEMBL3706408 | — | — | 1 | 5.14 |
| CHEMBL3706409 | — | — | 1 | 4.91 |
| CHEMBL3144303 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3144305 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3144171 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1199057 | — | EC50 | = | 651.0 | nM | 6.19 |
| CHEMBL3144153 | — | EC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL3144310 | — | EC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL574817 | — | EC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL607338 | — | EC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL3144180 | — | EC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL1230817 | — | EC50 | = | 6290.0 | nM | 5.20 |
| CHEMBL3706406 | — | EC50 | = | 6490.0 | nM | 5.19 |
| CHEMBL3706408 | — | EC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL3706409 | — | EC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL3144303 | — | EC50 | = | 27700.0 | nM | 4.56 |