Assay Detail
Binding
CHEMBL759297
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity of compound against the binding of human Peroxisome proliferator activated receptor delta was determined
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.78 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344282 | — | — | 1 | 6.13 |
| CHEMBL149438 | — | — | 1 | 6.06 |
| CHEMBL149676 | — | — | 1 | 5.92 |
| CHEMBL356170 | — | — | 1 | 5.82 |
| CHEMBL148639 | — | — | 1 | 5.77 |
| CHEMBL345721 | — | — | 1 | 5.70 |
| CHEMBL424133 | LY-518674 | 2.0 | 1 | 5.42 |
| CHEMBL148774 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344282 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL149438 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL149676 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL356170 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL148639 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL345721 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL424133 | LY-518674 | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL148774 | — | IC50 | = | 4100.0 | nM | 5.39 |