Assay Detail
Binding
CHEMBL759393
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Maximum transcriptional activation of human PPAR delta receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.22 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38508 | — | — | 1 | 9.00 |
| CHEMBL38943 | GW501516 | 2.0 | 1 | 9.00 |
| CHEMBL289887 | — | — | 1 | 8.00 |
| CHEMBL40614 | — | — | 1 | 7.70 |
| CHEMBL39894 | — | — | 1 | 7.52 |
| CHEMBL37013 | — | — | 1 | 7.52 |
| CHEMBL39687 | — | — | 1 | 7.22 |
| CHEMBL288341 | — | — | 1 | 7.05 |
| CHEMBL37495 | — | — | 1 | 6.38 |
| CHEMBL416794 | — | — | 1 | 6.33 |
| CHEMBL39129 | — | — | 1 | 5.72 |
| CHEMBL36268 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38508 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL38943 | GW501516 | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL289887 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL40614 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL39894 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL37013 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL39687 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL288341 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL37495 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL416794 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL39129 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL36268 | — | EC50 | = | 5900.0 | nM | 5.23 |